Stimulating Conversations: NeuroOne’s Second Podcast Episode
NeuroOne’s Second Podcast Episode Discusses Innovative, Game-Changing Devices That Will Redefine Modern Medicine
NeuroOne's podcast, “Behind the Electrodes,” welcomes guests from the field of neuroscience to provide insight on the developing technologies and practices relevant to doctors and patients alike.
In our second episode, Dr. Kip Ludwig, who leads the Bioelectronic Medicines Laboratory at the University of Wisconsin and serves on the NeuroOne Medical Technologies advisory board and as chairman of the AI advisory board, discusses the challenges of collecting data from the brain’s network of 100 billion plus neurons. While NeuroOne is developing the technology to gain a higher number of channels to access more neural information, it’s impossible for a human to process this information. Therefore, it’s important to utilize structures, such as artificial intelligence (AI), to make sense of this data and use advanced electrode technology for diagnostics and potentially to develop therapeutic tools.
The Future of Medicine
Dr. Ludwig explains that the ability to use an advanced neuromodulator may provide real-time treatment to patients with diseases such as Parkinson’s by monitoring abnormalities and delivering corrective electrical signals to the brain. Such an application represents a more sophisticated opportunity to extend NeuroOne product capabilities.
Ludwig and his team are researching the potential for electrode technology to interface with nerves in the periphery and for deep brain stimulation (DBS). Peripheral nerves are more accessible and present an opportunity for less invasive electrode technology to create an interface with deep nerves and potentially eliminate the use of drugs for hypertension and heart failure patients.
Together with his research team, they are also building and testing a transcutaneous multi-electrode array for stimulation of specific nerve plexuses in the spinal cord. This device, in tandem with physical therapy training, would be used to help victims of spinal cord injury regain motor functions in their lower extremities.
New Technologies on the Horizon
Dr.Ludwig cites two additional technologies that are game changers:
· An innovative micro-cardiac pacemaker system the size of thumb nail can be planted directly in the heart. Using a smart sensor instead of a wire, this advanced technology senses electrocardiogram, records the electrical signal from the heart and can change the pace if needed, while also sensing PH levels and, in the case of a heart attack, sending a signal to the clinician.
· Evo™ Cortical Electrodes (Evo), the first FDA-cleared thin-film electrodes for recording, monitoring and stimulating brain tissue for up to 30 days, are another game changer in the neurotechnology space. Evo is expected to soon hit the market, offering a thin film solution with the potential for hi-definition recordings. It also features modern day manufacturing systems that are fully automated and provide physicians customized electrode technology.
Ludwig is featured in our white paper “Thin Film Electrodes Show Potential for Transforming Neurosurgery,” stating, “I’m looking forward to seeing the NeuroOne thin-film electrode technology become widely available clinically. The flexible thin-film substrate is light years ahead of existing technology that is used clinically, and fundamentally much safer than current grids which use manufacturing processes that are easily 30 years out of date. The NeuroOne manufacturing process should be extensible to diverse areas in neuromodulation such as deep brain stimulation and spinal cord stimulation. One can imagine this platform technology soon being used to create patient specific electrode configurations to treat a host of diseases/disorders.”